GLP-1 medicines, such as Mounjaro, Wegovy, Saxenda, and newer treatments like Retatrutide and Survodutide, are becoming popular choices for those looking to lose weight sustainably. These medicines belong to a group of drugs that work by mimicking a hormone called GLP-1 (glucagon-like peptide-1), which can influence appetite, metabolism, and blood sugar control. For individuals seeking science-based weight loss and long-term transformation, these medications often provide promising results. However, while many people experience effective weight loss, there are some side effects associated with GLP-1 medications. Here’s a breakdown of the common ones and a few practical tips on managing them.

1. Nausea and Vomiting

Possibly the most common side effects people encounter with GLP-1 medicines are nausea and, occasionally, vomiting. Medications like Mounjaro, Saxenda, and Wegovy act on appetite-regulating centres in the brain, which can inadvertently trigger nausea. To reduce this discomfort, it’s helpful to start with a lower dose and gradually increase it, as this allows the body to adjust. Try to eat smaller meals, avoid greasy or spicy foods, and eat slowly, which can reduce the intensity of these symptoms. Hydration is key as well, as it helps the body process the medicine.

2. Diarrhoea and Constipation

Both diarrhoea and constipation can occur with these medicines. People may find that initially, bowel movements become unpredictable. Drinking plenty of water and including high-fibre foods in the diet can help maintain regularity. A simple tip: balance your fibre intake with adequate water, as too much fibre without water can actually worsen constipation. Additionally, gentle physical activity, like walking, may stimulate digestion and relieve discomfort. Personalised weight loss plans that consider dietary choices can also assist with managing this side effect effectively.

3. Fatigue

Fatigue is another side effect some users of GLP-1 medicines report. Since these drugs affect blood sugar levels, it’s essential to keep blood glucose steady by eating regular, balanced meals rich in nutrients. Incorporating a mix of protein, complex carbohydrates, and healthy fats can prevent dips in energy levels. Simple lifestyle changes, like light exercise and stress management techniques, can also boost energy levels and aid in overall weight loss efforts.

4. Headaches

Headaches are a relatively common side effect, and they may be linked to the body’s metabolic adjustments on GLP-1 medicines. Staying hydrated is crucial, as dehydration can contribute to headaches. Ensuring sufficient sleep and minimising caffeine intake may also help reduce headache frequency. Weight loss coaching and support groups focused on lifestyle changes can be helpful, providing advice and motivation for maintaining healthy hydration and stress levels, which can often trigger headaches.

5. Dizziness

Some users of GLP-1 medications, like Retatrutide and Wegovy, report feelings of dizziness, especially at the beginning of treatment. This can sometimes be attributed to changes in blood pressure or dehydration. If dizziness occurs, stand up slowly to avoid sudden changes in blood flow. Eating small, frequent meals may also help maintain stable blood sugar levels, reducing dizziness. For those with a busy lifestyle, meal planning and mindful eating practices can be effective strategies.

6. Injection Site Reactions

Many GLP-1 medications, including Mounjaro and Wegovy, are taken as injections. Some individuals may experience mild irritation or bruising at the injection site. To avoid these reactions, alternate the injection site each time and follow the instructions provided with the medication closely. If you continue to experience discomfort, speak with a healthcare professional about the best technique or other ways to minimise irritation.

When to Seek Medical Advice

While most side effects are manageable with these tips, some individuals might experience more severe symptoms, such as intense abdominal pain or signs of an allergic reaction (like swelling or difficulty breathing). If these occur, it’s vital to seek medical advice immediately, as they could signal a more serious reaction. Remember that all medications come with risks and benefits, and finding the right balance for effective weight management is key.

Final Thoughts

GLP-1 medications like Mounjaro, Saxenda, and Wegovy offer a promising option for those striving for sustainable weight loss and healthy weight maintenance. Although side effects can be challenging, many people find that with time and a few practical strategies, these effects become more manageable. For the best results, consider pairing GLP-1 therapy with holistic weight management techniques, including personalised dietary plans, portion control, exercise, and stress management for weight loss.